A new phenoxyacetate-based linker system for the solid-phase synthesis of oligosaccharides

Authors
Wu, XY Grathwohl, M Schmidt, RR
Citation
Xy. Wu et al., A new phenoxyacetate-based linker system for the solid-phase synthesis of oligosaccharides, ORG LETT, 3(5), 2001, pp. 747-750
Citations number
32
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
5
Year of publication
2001
Pages
747 - 750
Database
ISI
SICI code
1523-7060(20010308)3:5<747:ANPLSF>2.0.ZU;2-4
Abstract
[GRAPHICS] A novel linker system has been designed, and its first application to solid -phase oligosaccharide synthesis is described, The use of the highly reacti ve o-nitro-phenoxyacetate linker allows a fast and quantitative cleavage us ing mild basic conditions, This method combined with the trichloroacetimida te glycosylation exhibits highly promising results as demonstrated for the synthesis of tetrasaccharide 1 (n = 3) containing glucose beta (1 --> 4) an d beta (1 --> 6) linkages.