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A new class of 3-hetero-13,14-dihydro prostaglandin F-1 alpha analogues was
synthesized from a common intermediate. The latter was constructed via a t
wo-step, three-component process. The lower chain, containing the 15-(pheno
xymethyl) group, was synthesized in enantiopure form using Jacobsen's (sale
n)Co-catalyzed kinetic resolution of a terminal epoxide with phenol.