An efficient synthesis of 3-hetero-13,14-dihydro prostaglandin F-1 alpha analogues

Authors
Gu, JX Dirr, MJ Wang, YL Soper, DL De, B Wos, JA Johnson, CR
Citation
Jx. Gu et al., An efficient synthesis of 3-hetero-13,14-dihydro prostaglandin F-1 alpha analogues, ORG LETT, 3(5), 2001, pp. 791-794
Citations number
15
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
5
Year of publication
2001
Pages
791 - 794
Database
ISI
SICI code
1523-7060(20010308)3:5<791:AESO3P>2.0.ZU;2-5
Abstract
[GRAPHICS] A new class of 3-hetero-13,14-dihydro prostaglandin F-1 alpha analogues was synthesized from a common intermediate. The latter was constructed via a t wo-step, three-component process. The lower chain, containing the 15-(pheno xymethyl) group, was synthesized in enantiopure form using Jacobsen's (sale n)Co-catalyzed kinetic resolution of a terminal epoxide with phenol.