CYCLIC-AMP STIMULATES THE PROTEIN-TYROSINE KINASE-ACTIVITY OF ACINETOBACTER-CALCOACETICUS

Authors
GRANGEASSE C VAGANAY E DOUBLET P RIBERTY M COZZONE AJ DUCLOS B
Citation
C. Grangeasse et al., CYCLIC-AMP STIMULATES THE PROTEIN-TYROSINE KINASE-ACTIVITY OF ACINETOBACTER-CALCOACETICUS, FEMS microbiology letters, 152(2), 1997, pp. 333-337
Citations number
17
Categorie Soggetti
Microbiology
Journal title
FEMS microbiology letters → ACNP
ISSN journal
03781097
Volume
152
Issue
2
Year of publication
1997
Pages
333 - 337
Database
ISI
SICI code
0378-1097(1997)152:2<333:CSTPKO>2.0.ZU;2-1
Abstract
The protein tyrosine kinase activity of Acinetobacter calcoaceticus wa s analyzed in vitro through the specific phosphorylation of an endogen ous protein which is modified exclusively at tyrosine residues. A stro ng stimulation of this activity by cyclic AMP was observed. This findi ng represents the first example of a protein tyrosine kinase, in proka ryotes as well as in eukaryotes, whose functioning is cyclic nucleotid e-dependent.