Uterine leiomyoma with massive lymphocytic infiltration simulating malignant lymphoma - A case report with immunohistochemical study showing that theinfiltrating lymphocytes are cytotoxic T cells

Uterine leiomyoma with massive lymphoid infiltration is very rare and may s imulate malignant lymphoma. To the best of our knowledge, this is the first description of such a lesion occurring in an Oriental, and the ninth case in the English literature. A 50-year-old Taiwanese woman had urinary freque ncy and nocturia because of a uterine myoma. The myomectomy specimen was id entified as a well-defined tumor, 6.5-cm in diameter, the cut surface of wh ich was pale, white and whorled. A massive lymphocytic infiltration accompa nied by plasma cells and histiocytes was noted in the leiomyoma but not in the surrounding non-neoplastic myometrial fibers. Most infiltrating lymphoc ytes were positive for CD3 and T cell intracellular antigen-1, a cytotoxic marker. The postoperative course was uneventful, and the urinary symptoms i mproved within a 6-month follow-up period.