Outcome of fetal urinary tract anomalies associated with multiple malformations and chromosomal abnormalities

The purpose of this study was to identify prognostic factors and describe t he outcome of prenatally detected renal anomalies associated with multiple malformations and chromosomal defects. Forty-one fetuses were included in t he analysis. Prenatal ultrasound reports, neonatal records and autopsy info rmation were retrospectively reviewed. Prognostic factors associated with f etal echography and clinical and laboratory findings on admission were stud ied. Data were analyzed by univariate analysis in which variables associate d with adverse outcome were identified by the Chi-square test or Fisher exa ct test. The abnormalities associated with renal anomalies were divided int o three groups: chromosomal defects (21%), previously described syndromes a nd conditions (24%), and new sporadic conditions (55%). Of 41 children admi tted, 30 (76%) died during the perinatal period. The presence of oligohydra mnios was significantly associated with an adverse outcome (OR = 11, p = 0. 05), Male gender was a protective factor against death during the perinatal period (OR = 0.11, p = 0.01). In conclusion, prenatally detected renal ano malies associated with multiple malformations and chromosomal defects had a poor prognosis. The presence of oligohydramnios increased the risk of deat h, and male gender had a protective role against poor outcome. Copyright (C ) 2001 John Wiley & Sons, Ltd.