Cardiopulmonary resuscitation (CPR) is performed frequently by paramedics,
emergency department personnel, and inpatient physicians. Unfortunately, af
ter more than 40 years of practice and study, there are still many controve
rsies and unresolved treatment issues. This article focuses on four current
controversies in CPR: (1) the role of end-tidal CO2 (ETCO2) detection, (2)
the use of bicarbonate, (3) whether epinephrine is the optimal alpha agoni
st, and (4) whether amiodarone should replace Lidocaine as the initial anti
arrhythmic of choice in the treatment of ventricular fibrillation.