Enzymatic synthesis of galactosylated 1D-chiro-inositol and 1D-pinitol derivatives using the beta-galactosidase from Bacillus circulans

Authors
Hart, J Falshaw, A Farkas, E Thiem, J
Citation
J. Hart et al., Enzymatic synthesis of galactosylated 1D-chiro-inositol and 1D-pinitol derivatives using the beta-galactosidase from Bacillus circulans, SYNLETT, (3), 2001, pp. 329-332
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
3
Year of publication
2001
Pages
329 - 332
Database
ISI
SICI code
0936-5214(200103):3<329:ESOG1A>2.0.ZU;2-G
Abstract
The beta -D-galactosidase from Bacillus circulans regioselectively galactos ylates 1D-chiro-inositol and 1D-pinitol (1D-3-O-methyl-chiro-inositol) to g ive mono- and digalactosylated inositols in yields of up to 45%. The enzyme does not galactosylate 1L-chiroinositol or 1L-quebrachitol (1L-2-O-methyl- chiro-inositol). This is the first report of enzymatic glycosylation of chi ro-inositol and its derivatives.