A facile new method for the two-step substitution of hydroxy groups in primary alcohols for trifluoromethyl and pentafluoroethyl moieties

Authors
Sevenard, DV Kirsch, P Roschenthaler, GV Movchun, VN Kolomeitsev, AA
Citation
Dv. Sevenard et al., A facile new method for the two-step substitution of hydroxy groups in primary alcohols for trifluoromethyl and pentafluoroethyl moieties, SYNLETT, (3), 2001, pp. 379-381
Citations number
23
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
3
Year of publication
2001
Pages
379 - 381
Database
ISI
SICI code
0936-5214(200103):3<379:AFNMFT>2.0.ZU;2-U
Abstract
In an efficient procedure the nucleophilic trifluoromethylation and pentafl uoroethylation of alkyl triflates using (trifluoromethyl)- and (pentafluoro ethyl)trimethylsilane in the presence of anhydrous tetramethylammonium fluo ride is achieved giving 71-80% isolated yields.