Ds. Bose et Av. Narsaiah, Use of PyBOP as a convenient activator for the synthesis of nitriles from primary amides, SYNTHESIS-S, (3), 2001, pp. 373-375
Various types of primary carboxamides were reacted with benzotriazol-1-ylox
ytris(pyrrolidino)phosphonium hexafluorophosphate (PyBOP) and N-ethyldiisop
ropylamine to obtain the corresponding nitriles in high yields.