A novel method for the mild and selective amidation of diesters and the amidation of monoesters

Authors
Guo, ZR Dowdy, ED Li, WS Polniaszek, R Delaney, E
Citation
Zr. Guo et al., A novel method for the mild and selective amidation of diesters and the amidation of monoesters, TETRAHEDR L, 42(10), 2001, pp. 1843-1845
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
10
Year of publication
2001
Pages
1843 - 1845
Database
ISI
SICI code
0040-4039(20010304)42:10<1843:ANMFTM>2.0.ZU;2-H
Abstract
The selective monoamidation of diesters and amidation of esters mediated by Lewis acids are described. The selective amidations of dimethyl pyridine-2 ,5-dicarboxylate (I) and dimethyl 2,3-indole-dicarboxylate (4) with primary and secondary amines mediated by MgCl2 or MgBr2 under mild conditions gave the corresponding ester-amides in high yield. (C) 2001 Published by Elsevi er Science Ltd.