One-step synthesis of 4(3H)-quinazolinones

Authors
Deetz, MJ Malerich, JP Beatty, AM Smith, BD
Citation
Mj. Deetz et al., One-step synthesis of 4(3H)-quinazolinones, TETRAHEDR L, 42(10), 2001, pp. 1851-1854
Citations number
26
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
10
Year of publication
2001
Pages
1851 - 1854
Database
ISI
SICI code
0040-4039(20010304)42:10<1851:OSO4>2.0.ZU;2-2
Abstract
2-Fluoro substituted benzoyl chlorides undergo cyclocondensation with 2-ami no-N-heterocycles to form 4(3H)-quinazolinones. The reaction proceeds in mo derate yields with different combinations of benzoyl chlorides and 2-amino- N-heterocycles, The products generally precipitate from the reaction mixtur e and require no further purification. Two tetrafluoro quinazolinones were found to be moderately active against a number of tumor cell lines. (C) 200 1 Elsevier Science Ltd. All rights reserved.