Straightforward access to methyl-polyheterocycles from direct para-lithiation of 3-picoline

Authors
Mathieu, J Gros, P Fort, Y
Citation
J. Mathieu et al., Straightforward access to methyl-polyheterocycles from direct para-lithiation of 3-picoline, TETRAHEDR L, 42(10), 2001, pp. 1879-1881
Citations number
11
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
10
Year of publication
2001
Pages
1879 - 1881
Database
ISI
SICI code
0040-4039(20010304)42:10<1879:SATMFD>2.0.ZU;2-#
Abstract
Various heterocycles have been introduced on the 3-picoline nucleus via a r egioselective BuLi-Me2N(CH2)(2)OLi (BuLi-LiDMAE) mediated para-lithiation. Useful methyl-polyheterocycles were efficiently prepared by a one-pot lithi ation-stannylation-Stille coupling sequence. (C) 2001 Published by Elsevier Science Ltd.