5-exo atom transfer cyclisation onto alkynes mediated by copper(I) complexes

Authors
Clark, AJ Battle, GM Bridge, A
Citation
Aj. Clark et al., 5-exo atom transfer cyclisation onto alkynes mediated by copper(I) complexes, TETRAHEDR L, 42(10), 2001, pp. 1999-2001
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
10
Year of publication
2001
Pages
1999 - 2001
Database
ISI
SICI code
0040-4039(20010304)42:10<1999:5ATCOA>2.0.ZU;2-8
Abstract
Multidentate amine derived copper(I) halide complexes mediate the atom tran sfer radical cyclisation of 1-halo-N-propargylacetamides. While cyclisation of trichloro- and dichloroacetamide derivatives leads to alpha,beta -unsat urated gamma -lactams containing the gem-dihalide functional group, monohal oacetamides give rise to either cyclised atom transfer or reduction product s depending upon the solvent and catalyst used. (C) 2001 Elsevier Science L td. All rights reserved.