Versatile assembly of the 2-carboxybenzo[b]azepine ring system

Authors
Giacobbe, SA Di Fabio, R
Citation
Sa. Giacobbe et R. Di Fabio, Versatile assembly of the 2-carboxybenzo[b]azepine ring system, TETRAHEDR L, 42(10), 2001, pp. 2027-2029
Citations number
24
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
10
Year of publication
2001
Pages
2027 - 2029
Database
ISI
SICI code
0040-4039(20010304)42:10<2027:VAOT2R>2.0.ZU;2-A
Abstract
A suitable 2-carboxybenzo[b]azepine derivative was designed as a potential novel antagonist of the strychnine-insensitive glycine binding site of the NMDA receptor. This compound was synthesized via an N-aryl allylglycine, a useful intermediate efficiently prepared from the starting aniline derivati ve, followed by a short and unusual elaboration of the allyl double bond. ( C) 2001 Elsevier Science Ltd. All rights reserved.