Pr. Nambiar et al., Immunohistochemical detection of tumor suppressor gene p53 protein in feline injection site-associated sarcomas, VET PATH, 38(2), 2001, pp. 236-238
Citations number
19
Categorie Soggetti
Veterinary Medicine/Animal Health","Medical Research Diagnosis & Treatment
Sarcomas associated with injection sites are a rare but important problem i
n cats. Immunohistochemical detection of p53 protein may correlate to mutat
ion of the p53 tumor suppressor gene, a gene known to be important in oncog
enesis. The expression of nuclear p53 protein in 40 feline injection site-a
ssocated sarcomas was examined by immunohistochemical staining. In 42.5% (1
7/40), tumor cell nuclei were stained darkly; in 20% (8/40), tumor cell nuc
lei were stained palely; and in 37.5% (15/40), tumor cell nuclei were unsta
ined. Immunohistochemical detection of p53 protein in a proportion of injec
tion site-associated sarcomas suggests that mutation of the p53 gene may pl
ay a role in the pathogenesis of these tumors.