Quinolizidine alkaloid profiles of Lupinus varius orientalis, L-albus albus, L-hartwegii, and L. densiflorus

Alkaloid profiles of two Lupinus species growing naturally in Egypt (L. alb us albus [synonym L. rennis], L. varius orientalis) in addition to two New World species (L. hartwegii, L. densiflorus) which were cultivated in Egypt were studied by capillary GLC and GLC-mass spectrometry with respect to qu inolizidine alkaloids. Altogether 44 quinolizidine, bipiperidyl and proto-i ndole alkaloids were identified: 29 in L. albus, 13 in L. varius orientalis , 15 in L. hartwegii, 6 in L. densiflorus. Some of these alkaloids were ide ntified for the first time in these plants. The alkaloidal patterns of vari ous plant organs (leaves, flowers, stems, roots, pods and seeds) are docume nted. Screening for antimicrobial activity of these plant extracts demonstr ated substantial activity against Candida albicans, Aspergillus flavus and Bacillus subtilis.