Citation
K. Piippo et al., Effect of the antimalarial drug Halofantrine in the long QT syndrome due to a mutation of the cardiac sodium channel gene SCN5A, AM J CARD, 87(7), 2001, pp. 909
Citations number
18
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF CARDIOLOGY
ISSN journal
00029149
→ ACNP
Volume
87
Issue
7
Year of publication
2001
Database
ISI
SICI code
0002-9149(20010401)87:7<909:EOTADH>2.0.ZU;2-L
Abstract
We describe the first LQTS-causing mutation thus far localized in the S5 se
gment of the fourth SCN5A cardiac sodium channel domain. In 2 of mutation c
arriers, antimalarial therapy with halofantrine induced a marked prolongati
on of the QTc interval and torsades de pointes, demonstrating that specific
drag treatment may induce ventricular tachycardia in LQT3.