We have developed a series of laboratory tests to evaluate the efficiency o
f a heat and moisture exchanger tilter (Pall (TM) BB25) in retaining latex
particles in order to protect allergic patients during anaesthesia. Latex p
articles were nebulised with cornstarch as a support and collected for assa
y in a flask, with or without the filter integrated into the experimental c
ircuit. With the Pall BB25 filter in the circuit, no natural latex proteins
were detected by measurement of either total protein or antigenic latex pr
oteins. The Pall BB25 filter may represent a useful means of preventing inh
alation of latex particles during anaesthesia in susceptible patients.