Clinical studies with home glucose clamping

Objective : Self-blood glucose control is crucial to improving ling term ou tcomes in diabetes. To facilitate this task, we offered patients access to a remote computer continuously online for data collection, dosing decision support, and medical monitoring. Imbedded algorithms for home glucose clamp ing were custom programmed for each patient. The objectives of the present work were to determine what proportion of patients chose to use such suppor t and whether users benefited from the effort compared to non-users. Research design and methods : A single central computer system was used. Al gorithms for home glucose clamping were custom programmed for each patient by their physician who set glucose targets, clamping factors and safety con straints. The systems were voice-interactive and required the remote patien t to handle only a touch-tone telephone. Patients were free to access the s ystem each day to report self-measured blood glucose levels or hypoglycemia symptoms together with carbohydrate counting, planned exercise, stress, il lness or other life-style events. Clinical experience was in patients follo wed for 12 months in samples derived from three health-care environments. Results: Some 388 patients were offered access to the system. Sixty percent of patients (N = 231) actively used the system. Among the 3 study centers, over 104,000 blood glucose measurements were received during the start-up year. Each call was processed instantly and automatically. Patients benefit ed from the 24 hours access. Those receiving algorithmic assistance for hom e glucose clamping adjusted daily therapy more effectively: prevalence of h yper-glycemia and hypo-glycemia fell similar to 2-fold (p < 0.05) and glyca ted hemoglobin levels declined 1.3 % (p < 0.001). Conclusions: Physicians and patients benefited. Patients with diabetes may be receptive to computer assistance. Many can accomplish glucose clamping a t home and meet targets set by their physicians for self-blood glucose cont rol while reducing the incidence of diabetic crises. The centralized system adds no costs for the patients and empowers physicians to provide safer an d superior diabetes care.