Cutaneous pyoderma gangrenosum with hepatosplenic localization and monoclonal gammapathy. A case report.

Pyoderma gangrenosum is an ulcerative,disease of the skin. The histopatholo gical lesions are nonspecific, characterized by a diffuse neutrophilic infi ltrate in the dermis. Pyoderma gangrenosum is associated with inflammatory, digestive or articular disease, or acute or chronic hemotology disorders i n 50% of the cases, more rarely with monoclonal gammapathy, A visceral loca lization of pyoderma gangrenosum is rare, simulating a systemic disease or an underlying neoplasia. We report a case of cutaneous pyoderma gangrenosum with splenic and hepatic localizatios associated with an IgG monoclonal gammapathy, We emphasize th e efficacy of immunosuppressor treatment and the importance of long-term mo nitoring of these patients.