Diversity of Tn1546 elements in clinical isolates of glycopeptide-resistant enterococci from Scottish hospitals

Authors
Brown, AR Townsley, AC Amyes, SGB
Citation
Ar. Brown et al., Diversity of Tn1546 elements in clinical isolates of glycopeptide-resistant enterococci from Scottish hospitals, ANTIM AG CH, 45(4), 2001, pp. 1309-1311
Citations number
16
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
4
Year of publication
2001
Pages
1309 - 1311
Database
ISI
SICI code
0066-4804(200104)45:4<1309:DOTEIC>2.0.ZU;2-S
Abstract
The Tn1546-related elements of 48 Van glycopetide-resistant enterococci wer e compared. Ten distinct Tn1546 types were identified with variation primar ily due to IS1542 and IS1216V-like insertions. Clonal isolates frequently d iffered in their Tn1546 type, indicating instability of Tn1546-related elem ents. A putative hybrid promoter was identified, generated upstream of vanR by the insertion of IS1542, The presence of this hybrid promoter was assoc iated with constitutive expression of the van genes and elevated teicoplani n resistance.