In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophila

Authors
Ko, WC Lee, HC Chuang, YC Ten, SH Su, CY Wu, JJ
Citation
Wc. Ko et al., In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophila, ANTIM AG CH, 45(4), 2001, pp. 1281-1283
Citations number
15
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
4
Year of publication
2001
Pages
1281 - 1283
Database
ISI
SICI code
0066-4804(200104)45:4<1281:IVAIVC>2.0.ZU;2-I
Abstract
The activities of cefotaxime and minocycline against Aeromonas hydrophila w ere investigated, Cefotaxime {4 times the MIG) plus minocycline (0.75 times the MIC) elicited an inhibitory effect for 48 h in a time-kill study, and more infected mice treated with both drugs survived (91%) than survived aft er treatment with cefotaxime (9%) or minocycline (44%) alone, suggesting th at cefotaxime and minocycline act synergistically against A. hydrophila.