Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum: Potential surrogate marker in tuberculosis chemotherapy trials

Authors
Wallis, RS Phillips, M Johnson, JL Teixeira, L Rocha, LMMC Maciel, E Rose, L Wells, C Palaci, M Dietze, R Eisenach, K Ellner, JJ
Citation
Rs. Wallis et al., Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum: Potential surrogate marker in tuberculosis chemotherapy trials, ANTIM AG CH, 45(4), 2001, pp. 1302-1304
Citations number
8
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
4
Year of publication
2001
Pages
1302 - 1304
Database
ISI
SICI code
0066-4804(200104)45:4<1302:IOIEOM>2.0.ZU;2-5
Abstract
Mycobacterium tuberculosis antigen 85 is induced in vitro by isoniazid (INH ); its sustained induction in sputum during tuberculosis (TB) therapy predi cts relapse. In this trial, rifampin or rifalazil inhibited the induction o f sputum antigen 85 by INH in a dose-dependent fashion. This approach may f acilitate the evaluation of new TB drugs.