Novel sulfonate analogues of combretastatin A-4: Potent antimitotic agents

Authors
Gwaltney, SL Imade, HM Barr, KJ Li, Q Gehrke, L Credo, RB Warner, RB Lee, JY Kovar, P Wang, JY Nukkala, MA Zielinski, NA Frost, D Ng, SC Sham, HL
Citation
Sl. Gwaltney et al., Novel sulfonate analogues of combretastatin A-4: Potent antimitotic agents, BIOORG MED, 11(7), 2001, pp. 871-874
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
7
Year of publication
2001
Pages
871 - 874
Database
ISI
SICI code
0960-894X(20010409)11:7<871:NSAOCA>2.0.ZU;2-8
Abstract
Sulfonate analogues of combretastatin A-4 have been prepared. These compoun ds compete with colchicine and combretastatin A-4 for the colchicine bindin g site on tubulin and are potent inhibitors of tubulin polymerization and c ell proliferation. Importantly, these compounds also inhibit the proliferat ion of P-glycoprotein positive (+) cancer cells, which are resistant to man y other antitumor agents. (C) 2001 Elsevier Science Ltd. All rights reserve d.