Cis- and trans-N-benzyl-octahydrobenzo[g]quinolines. Adrenergic and dopaminergic activity studies

In vitro assays on a series of cis- and trans-octahydrobenzo[g]quinolines i ndicated an unusual trend of affinities at the dopaminergic receptors and c t adrenoceptors. The trans N-benzyl analogues exhibited affinity at the alp ha (2) as well as the D1-like receptors whereas their N-unsubstituted conge ners showed a distinct preference for the alpha (2) adrenoceptor. Enhanced activity for the alpha (2) receptors was also exhibited by the cia N-benzyl ated isomers. These observations are interpreted by theoretical calculation s. (C) 2001 Published by Elsevier Science Ltd.