The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil Elastase - GW311616A a development candidate

Authors
Mcdonold, SJF Dowle, MD Harrison, LA Shah, P Johnson, MR Inglis, GGA Clarke, GDE Smith, RA Humphreys, D Molloy, CR Amour, A Dixon, M Murkitt, G Godward, RE Padfield, T Skarzynski, T Singh, OMP Kumar, KA Fleetwood, G Hodgson, ST Hardy, GW Fincha, H
Citation
Sjf. Mcdonold et al., The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil Elastase - GW311616A a development candidate, BIOORG MED, 11(7), 2001, pp. 895-898
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
7
Year of publication
2001
Pages
895 - 898
Database
ISI
SICI code
0960-894X(20010409)11:7<895:TDOAPI>2.0.ZU;2-S
Abstract
The discovery of a potent intracellular inhibitor of human neutrophil elast ase which is orally active and has a long duration of action is described. The pharmacodynamic and pharmacokinetic properties of a trans-lactam develo pment candidate, GW311616A, are described. (C) 2001 Elsevier Science Ltd. A ll rights reserved.