Synthesis and biological evaluation of benzo[b]naphthyridones, a series ofnew topical antibacterial agents

Authors
Tabart, M Picaut, G Desconclois, JF Dutka-Malen, S Huet, Y Berthaud, N
Citation
M. Tabart et al., Synthesis and biological evaluation of benzo[b]naphthyridones, a series ofnew topical antibacterial agents, BIOORG MED, 11(7), 2001, pp. 919-921
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
7
Year of publication
2001
Pages
919 - 921
Database
ISI
SICI code
0960-894X(20010409)11:7<919:SABEOB>2.0.ZU;2-6
Abstract
We describe here the synthesis and biological evaluation of a series of ben zo[b]naphthyridones, a new family of tricyclic antibacterial compounds that have a Gram-positive spectrum of activity. RP60556A, one of the most poten t of these compounds, is bactericidal against multiresistant cocci, especia lly multiresistant Staphylococcus aureus strains. Its physico-chemical and biological properties make it particularly suitable for topical antibacteri al use. (C) 2001 Elsevier Science Ltd. All rights reserved.