Water-soluble propofol analogues with intravenous anaesthetic activity

Authors
Cooke, A Anderson, A Buchanan, K Byford, A Gemmell, D Hamilton, N McPhail, P Miller, S Sundaram, H Vijn, P
Citation
A. Cooke et al., Water-soluble propofol analogues with intravenous anaesthetic activity, BIOORG MED, 11(7), 2001, pp. 927-930
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
7
Year of publication
2001
Pages
927 - 930
Database
ISI
SICI code
0960-894X(20010409)11:7<927:WPAWIA>2.0.ZU;2-N
Abstract
Propofol (2,6-diisopropylphenol) is a widely used intravenous anaesthetic t hat is formulated as an emulsion since it lacks water solubility. We report a range of water-soluble analogues of propofol, containing a para-alkylami no substituent, which retain good intravenous anaesthetic activity in roden ts. (C) 2001 Elsevier Science Ltd. All rights reserved.