Bile acid-oligodeoxynucleotide conjugates: Synthesis and liver excretion in rats

Authors
Starke, D Lischka, K Pagels, P Uhlmann, E Kramer, W Wess, G Petzinger, E
Citation
D. Starke et al., Bile acid-oligodeoxynucleotide conjugates: Synthesis and liver excretion in rats, BIOORG MED, 11(7), 2001, pp. 945-949
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
7
Year of publication
2001
Pages
945 - 949
Database
ISI
SICI code
0960-894X(20010409)11:7<945:BACSAL>2.0.ZU;2-X
Abstract
The synthesis of bile acid-oligodeoxynucleotide conjugates via the 3-OH gro up of the bile acids is described. When used in vivo in rats, covalent conj ugation of an oligodeoxynucleotide via a linker to cholic acid resulted in an increased biliary excretion of bile acid-oligodeoxynucleotide conjugates compared to unconjugated oligodeoxynucleotides. (C) 2001 Elsevier Science Ltd. All rights reserved.