Dw. Kaufman et Jp. Kelly, Acetylsalicylic acid and other salicylates in relation to Stevens-Johnson syndrome and toxic epidermal necrolysis, BR J CL PH, 51(2), 2001, pp. 174-176
Aims Various nonsteroidal anti-inflammatory drugs are known to increase the
risk of Stevens-Johnson syndrome and toxic epidermal necrolysis. The relat
ionship between salicylate treatment and these conditions is not known.
Methods A case-control study was conducted in four countries in Europe from
1989 to 1995.
Results Among 373 cases and 1720 controls, the multivariate relative risk e
stimate for any salicylate use in the previous week was 1.3 (95% confidence
interval, 0.8-2.2); no statistically significant elevations were observed
for single ingredient preparations or for salicylate-containing combination
products.
Conclusions Acetylsalicylic acid and other salicylates are not associated w
ith a measurable increase in the risk of these rare but severe reactions.