W. Willenbacher et al., Treatment of steroid refractory acute and chronic graft-versus-host disease with daclizumab, BR J HAEM, 112(3), 2001, pp. 820-823
Competitive inhibition of interleukin 2-dependent lymphocytes by daclizumab
demonstrates some beneficial effects in the treatment of graft-versus-host
disease (GVHD), Sixteen patients with steroid refractory GVHD received dac
lizumab (1 mg/kg BW) on d 1, 2 (-5), 7, 14 and 21. Twelve patients suffered
from grade LU-nr acute GVHD and four patients from extensive chronic GVHD.
Responses were observed in nine patients (six acute, three chronic GVHD).
Fourteen out of 16 patients acquired infections during daclizumab treatment
and three deaths were infection related. Daclizumab demonstrates limited a
ctivity and is associated with an increased incidence of infectious complic
ations.