A 38-year-old male sans admitted io the intensive care unit with a ful
l-thickness burn involving 30 per cent of his total body surface area
(TBSA) and severe inhalation injury. Respiratory failure developed wit
hin 54 h and CO2 could not be eliminated, even by very invasive mechan
ical ventilation. Because of tile patient's age and the minor extent o
f the burned TBSA, we started extracorporeal CO2 elimination (ECCO2-X)
and continued ECCO2-R for 30 days, when the patient was weaned from E
CC. The clinical course during ECCO2-R was complicated by major bleedi
ng from a thoracotomy tube, from the site of tangential excision and b
y four septic episodes. Lung biopsy was performed twice on day 29 (dur
ing ECCO2-R) and day 58 (after ECCO2-R) after admission and revealed b
ronchiolitis obliterans without tendency to recovery. The patient died
of sepsis with multiorgan failure on day 81 after trauma. (C) 1997 El
sevier Science Ltd for ISBI.