THE UPTAKE OF CHOLESTEROL AT THE SMALL-INTESTINAL BRUSH-BORDER MEMBRANE IS INHIBITED BY APOLIPOPROTEINS

Authors
BOFFELLI D COMPASSI S WERDER M WEBER FE PHILLIPS MC SCHULTHESS G HAUSER H
Citation
D. Boffelli et al., THE UPTAKE OF CHOLESTEROL AT THE SMALL-INTESTINAL BRUSH-BORDER MEMBRANE IS INHIBITED BY APOLIPOPROTEINS, FEBS letters, 411(1), 1997, pp. 7-11
Citations number
24
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
411
Issue
1
Year of publication
1997
Pages
7 - 11
Database
ISI
SICI code
0014-5793(1997)411:1<7:TUOCAT>2.0.ZU;2-B
Abstract
The uptake of free and esterified cholesterol at the brush border memb rane is protein-mediated. Here we show that this sterol uptake is effe ctively inhibited by exchangeable serum apolipoproteins. Binding of th e apolipoprotein to the brush border membrane mediates the inhibitory effect. Evidence is presented to show that the structural motif respon sible for the inhibition is the amphipathic alpha-helix. (C) 1997 Fede ration of European Biochemical Societies.