Separation of chiral compounds by capillary electrophoresis

The article gives an overview of the state of the art of capillary electrop horesis in the field of chiral separations. The review covers basic princip les of separation of enantiomers by electromigration methods. Various separ ation modes, various chiral selectors, and separation mechanisms responsibl e for chiral recognition are shown. Factors affecting the resolution, such as concentration of chiral selector(s), electrolyte composition, its concen tration, pH, ionic strength, and addition of organic modifiers, are discuss ed. possibilities to use mathematical or semiempirical approaches for optim ization of the separation system are demonstrated on examples of the most f requently used chiral selectors - cyclodextrins.