Inferior liver allograft survival from cadaveric donors > 50 years of age?

The growing imbalance between the number of cadaveric organ donors and reci pients has led to an increasing use of high-risk donors as an option to exp and the donor pool. The aim of this study was to evaluate our experience wi th the use of older liver (donor > 50 yr of age) allografts. The medical records, postreperfusion biopsies and laboratory results were r eviewed of the 393 patients who underwent orthotopic liver transplantation between 1986 and 1997. The outcome of the 61 patients who received older li vers (OL) was compared to that of the other 332 recipients. Increasing use of OL was evident from 1992 onwards. Recipients of OL were o lder than recipients of younger livers (YL, p < 0.001) and more commonly ha d underlying chronic viral hepatitis (CVH) or fulminant hepatic failure (p < 0.051. Patient and allograft survival were only slightly less in recipien ts of OL versus YL (p = NS), Although postperfusion biopsies showed more da mage in OL than YL allografts (p ( 0.05), this was not associated with incr eased primary graft failure. OL allografts can be transplanted with accepta ble results into recipients without the concern of early allograft loss. Summary of Article: This report of one centre's experience with 61 recipien ts of older donor liver allografts identifies recipient factors that may al so have a negative impact on allograft outcome. These factors include a dia gnosis of either CVH or fulminant hepatic failure at the time of transplant ation. Postreperfusion biopsies of older donor allografts tend to show more damage, but this is not associated with primary non-function.