Purpose: To study etiologic aspects of hip dysplasia in a colony of Dutch-b
elted rabbits.
Methods: Rabbits used in the study were part of a reproductive toxicologic
study, Incidence of hip dysplasia among 296 Dutch-Belted rabbit kits raised
on waxed cardboard, smooth Plexiglas, or Plexiglas covered with textured a
dhesive strips was recorded. All animals were examined at 2 to 4 weeks of a
ge for inability to adduct one or more limbs, then were classified as norma
l or dysplastic, A subset of 16 juvenile male rabbits (4 normal, 12 affecte
d) raised on Plexiglas flooring were given a physical examination at 12 wee
ks of age followed by complete necropsy, In four animals tone normal, three
affected), pelvic radiography and neurologic examination were performed.
Results: Seven percent of the rabbits kits reared on waxed cardboard floori
ng and 22% of those reared on smooth Plexiglas flooring developed hip dyspl
asia, Animals reared on Plexiglas floor with traction strips did not have e
vidence of hip dysplasia, Among the animals selected for detailed analysis,
body weight was similar between rabbits with or without splay leg. Affecte
d animals had splaying of one or both hind limbs, various degrees of flatte
ning and reduction of the size of the femoral head, subluxation of the hip,
valgus deformity, and patellar luxation. Histologically, there was marked
thickening of the hip joint capsule with fibrocartilage formation, mild tra
becular bone loss, and bony sclerosis of the proximal portion of the femur
and adductor muscle hypoplasia,
Conclusions: Provision of non-slippery flooring during the postnatal period
is critical in preventing development of hip dysplasia in rabbits. Hip dys
plasia resulted in significant musculoskeletal changes, but not abnormal ne
urologic development.