Differential alterations in plasma colony-stimulating factor concentrations after coronary artery bypass graft surgery with extracorporeal circulation

To determine whether colony-stimulating factor (CSF) might participate to t he inflammatory response after cardiac surgery, plasma concentrations of gr anulocyte-CSF (G-CSF), macrophage-CSF (M-CSF) and GM-CSF were measured in 3 1 patients undergoing coronary artery bypass graft (CABG) surgery with extr acorporeal circulation (ECC), Plasma G-CSF and M-CSF concentrations increas ed after weaning of ECC, reached maximum value at the sixth post-operative hour, and remained elevated at the 24th post-operative hour. In contrast, p lasma GM-CSF levels did not change. Plasma M-CSF, G-CSF and GM-CSF values w ere not different whether patients developed post-operative complications o r not. In conclusion, M-CSF and C-CSF are produced after CABG surgery despi te the use of high aprotinin doses in hope to abrogate the inflammatory res ponse. G-CSF and M-CSF might play a role in the inflammatory process often observed after CABG surgery.(C) 2001 Academic Press.