Growth and nutrition in Rett syndrome

Purpose/Method: In this paper we review the existing literature on factors that contribute to growth failure in Rett syndrome (RS) with particular emp hasis on the extent and nature of the feeding: difficulties that arise. Dat a on growth and feeding related problems, collected over four years in a sp ecialized clinic for females with Rett syndrome are presented and managemen t protocols developed in the clinic discussed. Results/Conclusion: Feeding related problems and growth failure occur commo nly in Rett syndrome yet our understanding of the mechanisms causing growth failure are poorly understood. Both nutritional and non-nutritional factor s are thought to contribute and it has not been possible to develop efficac ious intervention strategies. Consequently, clinical management of growth f ailure in Rett syndrome is not evidence based.