Malignant mixed mullerian tumor of the ovary: report of four cases

Introduction: Malignant mixed mullerian tumor (MMMT) of the ovary is an ext remely rare gynaecologic neoplasm that represents 1% of the malignances of this organ. Stage I disease is rare because it is asymptomatic in early sta ge. We describe four cases. Case reports. In the Department of Obstetrics and Gynecology of the Univers ity of Bari four cases of MMMT of the ovary were diagnosed. Three patients were in stage IIIC and one of them was a homologous MMMT, the fourth patien t was affected by a heterologous stage IV MMMT. All women were treated with surgery and chemotherapy. Two patients are alive 14 and 12 months after di agnosis. The other two died after 37 months and one month, respectively. Conclusions: The malignant mixed mullerian tumor (MMMT) of the ovary is a p articularly aggressive tumor, especially in advanced stages. The survival r ate is very low in spite of surgery, chemotherapy and radiotherapy. The opt imal treatment for this neoplasm is unknown because of its rarity. Our expe rience, when considering survival, seems to confirm the use of cisplatin an d ifosfamide and to give new horizons to taxol.