Synthesis and anti-inflammatory activity of l-acetyl-5-substitute daryl-3-(beta-aminonapthyl)-2-pyrazolines and beta-(substituted aminoethyl) amidonaphthalenes

The title compounds were prepared by reaction of P-acetylamino-naphthalene with different aromatic aldehydes followed by cyclisation with hydrazine hy drate and with different primary or secondary amines (Mannich's reaction), respectively. The structures of new compounds were confirmed by H-1-NMR and IR spectral data. Anti-inflammatory and ulcerogenic activities in vivo wer e evaluated and compared with the standard drugs, phenylbutazone and indome thacin. Some compounds of the series exhibited promising anti-inflammatory activity with a lower ulcerogenic liability than the standard drugs. (C) 20 01 Editions scientifiques et medicales Elsevier SAS.