A 64-year old female patient was treated for a therapy-resistant generalize
d granuloma annu[are with fumaric acid esters (Fumaderm (R) initial). One w
eek following begin of therapy with an initial dose of 30 mg per day, the p
apules had regressed significantly. A 6-week thera py with a final dose of
90 mg Fumaderm (R) initial per day led to a nearly complete healing of the
illness.