Synthesis of 5-spiro (5 '-methylisatin)-4-acetyl-2-(acetylamino)-Delta(2)-1,3,4-thiadiazoline and 5-spiro(5 '-methylisatin)-4-acetyl-2-(5 '-methylisatin-3 '-hydrazino)-Delta(2)-1,3,4-thiadiazoline

Authors
Islam, R Abedin, MJ Khayer, K Islam, MR
Citation
R. Islam et al., Synthesis of 5-spiro (5 '-methylisatin)-4-acetyl-2-(acetylamino)-Delta(2)-1,3,4-thiadiazoline and 5-spiro(5 '-methylisatin)-4-acetyl-2-(5 '-methylisatin-3 '-hydrazino)-Delta(2)-1,3,4-thiadiazoline, I J CHEM B, 40(3), 2001, pp. 240-242
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
40
Issue
3
Year of publication
2001
Pages
240 - 242
Database
ISI
SICI code
0376-4699(200103)40:3<240:SO5('>2.0.ZU;2-3
Abstract
Condensation of 5-methylisatin 1 with thiosemicarbazide in glacial acetic a cid gives 5-methylisatin-3-thiosemicarbazone 2, whereas with thiocarbohydra zide gives bis-5-methylisatin-3-thiocarbohydrazone 3. Acetylation of 2 and 3 with acetic anhydride affords 5-spiro (5'-methylisatin)-4-acetyl-2-(acety lamino)-Delta (2)-1,3,4-thiadiazoline 4 and 5-spiro(5'-methylisatin)-4-acet yl-2-(5'-methylisatin-3'-hydrazino)-Delta (2)-1,3,4-thiadiazoline 5 hydride furnishes 1,1'-N,N-dimethylated product 6.