Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary Cryptococcus neoformans infection

Authors
Feldmesser, M Kress, Y Casadevall, A
Citation
M. Feldmesser et al., Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary Cryptococcus neoformans infection, INFEC IMMUN, 69(4), 2001, pp. 2723-2727
Citations number
36
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
4
Year of publication
2001
Pages
2723 - 2727
Database
ISI
SICI code
0019-9567(200104)69:4<2723:ICFAAM>2.0.ZU;2-6
Abstract
Rod like crystalline structures formed during eosinophilic Cryptococcus neo formans pneumonia in C57BL/6 mice. Crystals were found associated,vith yeas t cells and free in host cell cytoplasm. The crystals apparently formed bec ause of the interaction of a host protein with the cryptococcal polysacchar ide. Crystal formation likely contributes to pathogenesis by causing cellul ar damage.