Protective role of lung surfactant protein D in a murine model of invasivepulmonary aspergillosis

Authors
Madan, T Kishore, U Singh, M Strong, P Hussain, EM Reid, KB Sarma, PU
Citation
T. Madan et al., Protective role of lung surfactant protein D in a murine model of invasivepulmonary aspergillosis, INFEC IMMUN, 69(4), 2001, pp. 2728-2731
Citations number
30
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
4
Year of publication
2001
Pages
2728 - 2731
Database
ISI
SICI code
0019-9567(200104)69:4<2728:PROLSP>2.0.ZU;2-S
Abstract
The protective effects of intranasal administration of amphotericin B (AmB) , human SP-A, SP-D and a 60-kDa fragment of SP-D (rSP-D) were examined in a murine model of invasive pulmonary aspergillosis (IPA). The untreated grou p of IPA mice showed no survival at 7 days postinfection. Treatment with Am B, SP-D, and rSP-D increased the survival rate to 80, 60, and 80%, respecti vely, suggesting that SP-D (and rSP-D) can protect immunosuppressed mice fr om an otherwise fatal challenge with Aspergillus fumigatus conidia.