HLA-A*01-restricted cytotoxic T-lymphocyte epitope from the Plasmodium falciparum circumsporozoite protein

Authors
Kumar, A Kumar, S Le, TP Southwood, S Sidney, J Cohen, J Sette, A Hoffman, SL
Citation
A. Kumar et al., HLA-A*01-restricted cytotoxic T-lymphocyte epitope from the Plasmodium falciparum circumsporozoite protein, INFEC IMMUN, 69(4), 2001, pp. 2766-2771
Citations number
29
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
4
Year of publication
2001
Pages
2766 - 2771
Database
ISI
SICI code
0019-9567(200104)69:4<2766:HCTEFT>2.0.ZU;2-E
Abstract
Here, we report the identification of a novel CD8(+) cytotoxic T-lymphocyte epitope on the Plasmodium falciparum circumsporozoite protein (3D7; amino acids 310 to 319 [EPSDKHIKEY]) that is restricted by HLA-A*01 and is recogn ized by human volunteers immunized with irradiated P. falciparum sporozoite s. HLA-A*01 is the second most common HLA allele among Caucasians.