Cellular angiofibroma of the vulva with DNA ploidy analysis

Cellular angiofibroma (CAF) is a recently described rare soft tissue neopla sm of the vulva (with only four reported cases) that typically occurs as a well-circumscribed solid rubbery vulvar mass in middle-aged women. The dist inct histologic features of bland spindle cells admired with numerous hyali nized medium to small blood vessels, and a vimentin-positive desmin-negativ e immunoprofile differentiates this neoplasm from other vulvar tumors such as angiomyofibroblastoma and aggressive angiomyxoma. Tn this report an addi tional case of CAF is presented with DNA ploidy analysis and CD99 immunohis tochemistry.