Use of ultrasound to prepare lipid emulsions of lorazepam for intravenous injection

Lipid emulsions can be used as a vehicle for the production of low-volume i njectable preparations with minimally water-soluble active ingredients. Fir st, we focus on the galenic and technological conditions established by ult rasound techniques. A 2(5) factorial design was used to optimize the carrie r emulsion. The study then deals with the development of a parenteral emuls ion formulation for lorazepam (1 mg/ml), which is compared with the highest concentration (0.05 mg/ml) achieved in the optimal aqueous diluent for lor azepam (dextrose 5% in water). The physical and chemical stability of loraz epam in the emulsion was examined for 7 months. (C) 2001 Elsevier Science B .V. All rights reserved.