An ophthalmic formulation of a beta-adrenoceptor antagonist, levobetaxolol, using poly(acrylic acid) nanoparticles as carrier: Loading and release studies
Tk. De et As. Hoffman, An ophthalmic formulation of a beta-adrenoceptor antagonist, levobetaxolol, using poly(acrylic acid) nanoparticles as carrier: Loading and release studies, J BIOACT C, 16(1), 2001, pp. 20-31
Poly(acrylic acid) (PAA) nanoparticles were synthesized by reverse microemu
lsion polymerization using an oil-soluble initiator. The particles had a na
rrow size range, similar to 50 nm, and were stable in phosphate buffer. The
particles were recovered and lyophilized in dry powder form and were redis
persible in buffer. The drug levobetaxolol was loaded into the nanoparticle
s from aqueous drug solutions. When the drug-loaded particles were disperse
d in a phosphate buffer solution the drug was released over several hours.
The drug formulation in PAA nanoparticles was stable for more than 2 months
at 4 degreesC and at room temperature.