Purpose: To report the reliability and validity of the Functional Assessmen
t of Cancer Therapy-Ovarian (FACT-O) in a consecutive series of outpatients
with epithelial ovarian cancer.
Patients and Methods: Two hundred thirty-two ovarian cancer patients attend
ing an outpatients gynecologic oncology clinic completed questionnaires at
baseline. The patients' FACT-O scores were compared with their performance
status, disease stage, treatment status, and other factors hypothesized to
be related to quality of life. Patients received a second questionnaire eit
her one week after baseline to assess the instrument's test-retest reliabil
ity and/or two months after baseline to evaluate its sensitivity to change
in performance status.
Results: Infernal consistency and test-retest reliability of the FACT-O wer
e adequate. Overall, the scales correlated with other measures as expected;
all correlations were in the hypothesized direction, patients with advance
d disease, poor performance status, and who were receiving active treatment
had lower scores on physical, functional, and ovarian cancer-specific scal
es. The total FACT-O and emotional well-being scores were lower for patient
s with poor performance status and patients in active treatment. The FACT-O
total and all subscale scores except emotional well-being were sensitive t
o decreases in performance status.
Conclusion: Overall, the FACT-O provides a reliable and valid assessment of
the quality of life of women with ovarian cancer, and is appropriate as a
brief quality of life assessment in clinical trials and descriptive studies
. (C) 2001 by American Society of Clinical Oncology.