Gm. Nicholas et al., Cortamidine oxide, a novel disulfide metabolite from the New Zealand basidiomycete (mushroom) Cortinarius species, J NAT PROD, 64(3), 2001, pp. 341-344
Three disulfide metabolites were isolated from the fruiting bodies of the b
asidiomycete (mushroom) Cortinarius sp., collected in the Catlins, New Zeal
and. The structures of these compounds were determined as the unsymmetrical
disulfide cortamidine oxide (1), 2,2 ' -dithiobis(pyridine N-oxide) (2), a
nd the symmetrical disulfide 3. Both 1 and 2 showed significant antimicrobi
al activity and cytotoxicity. 2,2 ' -Dithiobis(pyridine N-oxide) (2) and th
e symmetrical disulfide 3 are assumed to be artifacts of the isolation proc
edure.